Objective: to study the relationship of gene polymorphisms of the b-adrenoreception system with the risk of atrial fibrillation in patients with heart failure.
Material and methods. 286 patients with heart failure on the background of post-infarction cardiosclerosis were included. Of these, 25 (8.7%) patients had the atrial fibrillation. The genotyping was performed using 4 polymorphisms (Gly389Arg of the b1-adrenoreceptors gene, Ser49Gly of the b1-adrenoreceptors gene, Gln27Glu of the b2-adrenoreceptors gene and Ser275 of the b3-subunit of G-protein gene) using the polymerase chain reaction. The genetic and epidemiological analysis was carried out using the SNPStats program.
Results. Patients with heart failure with the G / C genotype of Gly389Arg polymorphism of the b1-adrenoreceptors gene have a lower risk of developing atrial fibrillation (OR = 0.14 (0.03-0.61), p = 0.0043, co-dominant model of heredity).
The data on a decrease in the risk of atrial fibrillation in patients with heart failure and with the G / C genotype Gly389Arg polymorphism of the b1-arenoreceptors gene are also confirmed in the overdominant (OR = 0.15 (0.03-0.64), p = 0.0012), as well as in the dominant (OR = 0.23 (0.08-0.69), p = 0.0029) and the log-additive (OR = 0.40 (0.17-0.94), p = 0.019) models.
Findings. The results allow us concluding that congenital genetic differences in the pathways of b-adrenoreception can be associated with the development of atrial fibrillation in patients with heart failure.
Keywords: atrial fibrillation, b1-adrenergic receptors, b2-adrenergic receptors, G-protein, heart failure, polymorphism, gene, risk.