The effect of the “low triiodothyronin syndrome” (LT3S) (according to the criterion of T3f ≤ 2 pmol / l) on the course of heart failure (HF) was studied.
The biennial study included 157 patients with HF (with a history of myocardial infarction against coronary heart disease). During hospitalization, a standardized assessment was carried out, hemodynamic parameters, clinical and biochemical blood tests, levels of thyroid hormones (thyroid stimulating hormone (TSH), free T3f and T4f, reverse T3r) were determined.
The frequency of the “Low T3” syndrome in patients with HF during hospitalization is 17.2%. Patients with this syndrome are younger, have poorer interheart hemodynamics, less toler-ance to physical activity (higher NYHA functional class), and less favorable course of HF (greater frequency of coronary interventions, and repeated hospitalizations) compared with patients with HF without the LT3S. A regression model of the probability of re-hospitalization of patients with HF was obtained. In patients with HF who had repeated hospitalization within 2 years, there was a significantly lower level of T3f (1.91 pmol / l versus 3.22), a smaller number of granulocytes (by 7.9%; p = 0.011) and leukocytes ( 5.6%) in blood, and large values of body mass index (by 16.2%) and systolic blood pressure (by 5.0%), a lower concentration of T3r (256.19 pg / ml versus 314.45 pg / ml).
Key words: thyroid hormones, “low T3” syndrome, heart failure, repeated hospitalization, regression model.
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