The purpose: to study the relationship of beta-adrenoreception gene polymorphisms with a heart failure.
Materials and methods. 285 patients with heart failure on the background of post-infarction cardiosclerosis were included. The genotyping was performed using 4 polymorphisms (Gly389Arg of the b1-adrenoreceptors gene, Ser49Gly of the b1-adrenoreceptors gene, Gln27Glu of the b2-adrenoreceptors gene and Ser275 of the b3-subunit of G-protein gene) using the polymerase chain reaction. For two years of follow-up, among 285 patients with a heart failure, 81 (28.4%) had re-hospitalization. During this period, 18 patients died (6.3%). 93 patients (32.6%) had a combined endpoint. The genetic and epidemiological analysis was carried out using the SNPStats program.
Results and discussion. The allele A of a Ser49Gly polymorphism (c.145A> G) of a beta1-adrenoreception gene is associated with a reduced risk of combined endpoint in patients with a heart failure (OR = 0.52 (0.28-0.96), p = 0.032, dominant model and OR = 0.51 (0.28 - 0.92), p = 0.02 in the log-additive inheritance model). This allele of a Ser49Gly polymorphism (c.145A> G) of a beta1-adrenoreceptor gene is also associated with a decrease in the frequency of rehospitalization (OR = 0.50 [0.26-0.95], p = 0.028, the dominant model and OR = 0.49 (0.26-0.92) , p = 0.019 for the log additive model). The allele G of Gln27Glu polymorphism (c.79C> G) of a beta2-adrenergic receptor gene increases the risk of a combined endpoint in patients with a heart failure (OR = 1.76 (1.04-2.96), p = 0.032, the dominant model of inheritance and OR = 1.75 (1.06- 2.90), p = 0.029 for an over-dominant model). No significant effect of the Gly389Arg polymorphism (c.1165G> C) of the beta1-adrenergic receptor gene and the Ser275 polymorphism (c.79C> G) of the beta-3 subunit of the G-protein on the course of heart failure was revealed.
Conclusions. The results allow us concluding that the features of the course of heart failure may have associations with genetic differences in the pathways of beta-adrenoreception.
Key words: b1-adrenergic receptors, b2-adrenergic receptors, G-protein, heart failure, polymorphism, gene, risk, course of the disease